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MASCC Antiemetics Study Group

Chair: Matti Aapro, MD ( - Switzerland
Vice-Chair: Bernardo Rapoport, MD ( - South Africa
Vice-Chair: Rita Wickham PhD, RN, AOCN ( - USA

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FDA Approves Rolapitant for Chemotherapy-Induced Nausea and Vomiting
On September 2, 2015, the US Food and Drug Administration (FDA) approved rolapitant (Varubi™) for the prevention of chemotherapy-induced nausea and vomiting (CINV). Rolapitant, developed by Tesaro, Inc., is a selective and competitive neurokinin 1 (NK-1) receptor antagonist. Rolapitant, neither an inducer nor inhibitor of the metabolic enzyme CYP3A4, is less likely to interact with other drugs, especially chemotherapy metabolized by CYP3A4. The approval was based on phase III clinical trials headed by Bernrdo Rapoport and Lee Schwartzberg.  >> Read More

FDA and EU Commission Approval for Netupitant/Palonosetron (Akynzeo)
In October, 2014, the FDA approved Akynzeo for control of nausea and vomiting in patients undergoing chemotherapy. Akynzeo, developed by Helsinn Healthcare S.A., is a fixed combination capsule that combines the two drugs, netupitant and palonosetron. The effectiveness of Akynzeo was established in three studies headed by Paul Hesketh, Richard Gralla, and Matti Aapro. >> Read More


History and Purpose

The Antiemetic Study Group was originally established as a subcommittee of MASCC to address the control of nausea and vomiting induced by chemotherapy and radiotherapy. At the 1995 MASCC Annual Meeting in Luxembourg, the group organized a consensus conference on the use of antiemetics. To identify the most important topics on which consensus should be measured and developed, the group constructed a questionnaire and circulated it to experts. The results, published in Supportive Care in Cancer, identified eight major issues that served as the basis for the conference (Ballatori et al, Support Care Cancer 1997; 5: 269-273). The Consensus Conference was held in Perugia, Italy, 28-29 April 1997, and results were published in the ESMO journal, Annals of Oncology (Ann Oncol.1998; 9: 811-819).

In the following years, the Study Group has worked in two directions. First, because various guideline recommendations for antiemetic prophylaxis (from, for example, the ASCO, ESMO, MASCC, NCON, and ASHP) differed, a unified consensus conference was held in New York. 19-20 April 2001. The final document of the conference was presented during the ASCO-MASCC Joint Session held in San Francisco, 14 May, 2001. 

Second, the members of the Study Group have always been most concerned about the moderate transfer of knowledge from clinical trials to clinical practice. The Study Group thus planned an international drug utilization study to study antiemetic prescriptions and effectiveness with respect to delayed emesis induced by chemotherapy. Despite optimal prophylaxis, this remains one of the unsolved problems of antiemetic therapy.




A Guide to Oncology Symptom Management 
Edited by C.G. Brown. 2010 20% MASCC Discount. This best-selling book offers a complete overview of common symptoms and problems that affect patients with cancer. Topics include common symptoms such as chemotherapy-induced nausea and vomiting, cancer-related fatigue, and oral mucositis, as well as symptoms in older adults.

Books on Supportive Care  >>VIEW ALL - MASCC Member Discountsalt

MASCC Endorsed Guideline Partnerships

Guideline for the Prevention and Treatment of Anticipatory Nausea and Vomiting Due to Chemotherapy in Pediatric Cancer Patients
The Pediatric Oncology Group of Ontario (POGO) has published "Guideline for the Prevention and Treatment of Anticipatory Nausea and Vomiting due to Chemotherapy in Pediatric Cancer Patients” (April 2014). This evidence-based guideline contains recommendations for optimizing control of anticipatory nausea and vomiting  in children from 1 month to 18 years of age who are receiving chemotherapy. Recommendations for both pharmacological and nonpharmacological interventions are included.  >> Read the Guideline

*Disclaimer* The evidence used in formulating this guideline was rated as "low level" by the authors and much of it was derived from evidence in the adult population, rather than a pediatric population. While the conclusions have face validity, the strength of the recommendations is limited by a dearth of high-quality data. There remains a need for more studies in the pediatric population.

Acute AINV Guideline for Pediatric Cancer Patients
The Pediatric Oncology Group of Ontario (POGO) has published “Guideline for the Prevention of Acute Nausea and Vomiting due to Antineoplastic Medication in Pediatric Cancer Patients” (April 2014). The purpose of this guideline is to provide healthcare providers with an approach to the prevention of acute antineoplastic-induced nausea and vomiting (AINV) in children. The scope is limited to the prevention of AINV in the acute phase (within 24 hours of antineoplastic administration).  >> Quick Review Summary


Please contact the Study Group Chairs above with your questions.
MASCC Study Group Coordinator, Anne Young





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