MASCC/ISOO Mucositis Clinical Practice Guidelines
©MASCC, Multinational Association for Supportive Care in Cancer™ •  All rights reserved worldwide. 


2019 Guidelines Update - July 2019

MASCC is pleased to announce the latest update of the MASCC/ISOO Clinical Practice Guidelines for the Management of Mucositis Secondary to Cancer Therapy. MASCC’s Mucositis Study Group published an editorial and seven articles in a Special Section of Supportive Care in Cancer in July, 2019. The papers are available via open access until August 8, 2020. (Please log in below for links to the papers.) This is the first set of papers generated as part of this guideline update, and it represents several types of interventions for oral mucositis: anti-inflammatory agents; photobiomodulation therapy (light and laser therapy); vitamins, minerals, and nutritional supplements; and protocols categorized as basic oral care. An entire paper is dedicated to interventions for the management of gastrointestinal mucositis. 

In addition, the Mucositis Study Group conducted a systematic review about the current understanding of the pathogenesis of mucositis. It is presented along with the clinical papers and extends the 2004, 2007, and 2014 systematic reviews of mucositis pathogenesis.

A revised summary of the MASCC/ISOO Clinical Practice Guidelines for the Management of Mucositis Secondary to Cancer Therapy will be available after a second set of papers is published in a future issue of Supportive Care in Cancer. These guidelines provide the current evidence-based standard of care for mucositis and represent the benchmark for future trials.

2019 Guidelines Translations
Translations in several languages will be available soon.

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Current Guideline Publications

2019 Guidelines Updates - Supportive Care in Cancer, July 2019
The first stage of the latest Mucositis Guideline update comprises an editorial and seven articles in a Special Section of Supportive Care in Cancer (July 2019). These papers cover several types of interventions for oral mucositis: anti-inflammatory agents; photobiomodulation; vitamins, minerals, and nutritional supplements; and protocols categorized as basic oral care. An entire paper is dedicated to interventions for the management of gastrointestinal mucositis. A revised edition of the MASCC/ISOO Clinical Practice Guidelines for the Management of Mucositis Secondary to Cancer Therapy will be available after a second set of papers is published in a future volume Supportive Care in Cancer. These guidelines represent the benchmark for future trials aimed at improving preventative and therapeutic approaches to mucositis in several settings of cancer disease and treatment.

  • The MASCC/ISOO Mucositis Guidelines 2019 Update: Introduction. Sharon Elad.

  • Development of the MASCC/ISOO Clinical Practice Guidelines for Mucositis: An Overview of the Methods. Vinisha Ranna, Karis Kin Fong Cheng, Daniel A. Castillo, Lorraine Porcello, Anusha Vaddi, Rajesh V. Lalla, Paolo Bossi, Sharon Elad.

  • Systematic Review of Photobiomodulation for the Management of Oral Mucositis in Cancer Patients and Clinical Practice Guidelines. Yehuda Zadik, Praveen R. Arany, Eduardo Rodrigues Fregnani, Paolo Bossi, Héliton Spindola Antunes, René-Jean Bensadoun, Luiz Alcino Gueiros, Alessandra Majorana, Raj G. Nair, Vinisha Ranna, Wim J. E. Tissing, Anusha Vaddi, Rachel Lubart, Cesar Augusto Migliorati, Rajesh V. Lalla, Karis Kin Fong Cheng, Sharon Elad.

  • Systematic Review of Natural and Miscellaneous Agents for the Management of Oral Mucositis in Cancer Patients and Clinical Practice Guidelines. Part 1: Vitamins, Minerals, and Nutritional Supplements. Noam Yarom, Allan Hovan, Paolo Bossi, Anura Ariyawardana, Siri Beier Jensen, Margherita Gobbo, Hanan Saca-Hazboun, Abhishek Kandwal, Alessandra Majorana, Giulia Ottaviani, Monica Pentenero, Narmin Mohammed Nasr, Tanya Rouleau, Anna Skripnik Lucas, Nathaniel Simon Treister, Eyal Zur, Vinisha Ranna, Anusha Vaddi, Karis Kin Fong Cheng, Andrei Barasch, Rajesh V. Lalla, Sharon Elad.

  • Systematic Review of Anti-inflammatory Agents for the Management of Oral Mucositis in Cancer Patients and Clinical Practice Guidelines. Anura Ariyawardana, Karis Kin Fong Cheng, Abhishek Kandwal, Vanessa Tilly, Abdul Rahman Al-Azri, Dimitra Galiti, Karen Chiang, Anusha Vaddi, Vinisha Ranna, Ourania Nicolatou-Galitis, Rajesh V. Lalla, Paolo Bossi, Sharon Elad.

  • Systematic Review of Basic Oral Care for the Management of Oral Mucositis in Cancer Patients and Clinical Practice Guidelines. Catherine H. L. Hong, Luiz Alcino Gueiros, Janet S. Fulton, Karis Kin Fong Cheng, Abhishek Kandwal, Dimitra Galiti, Jane M. Fall-Dickson, Jorgen Johansen, Suzanne Ameringer, Tomoko Kataoka, Dianna Weikel, June Eilers, Vinasha Ranna, Anusha Vaddi, Rajesh V. Lalla, Paolo Bossi, Sharon Elad.

  • The Pathogenesis of Mucositis: Updated Perspectives and Emerging Targets. J. Bowen, N. Al-Dasooqi, P. Bossi, H. Wardill, Y. Van Sebille, A. Al-Azri, E. Bateman, M. E. Correa, J. Raber-Durlacher, A. Kandwal, B. Mayo, R. G. Nair, A. Stringer, K. Ten Bohmer, D. Thorpe, R. V. Lalla, S. Sonis, K. Cheng, S. Elad.

  • Systematic Review of Agents for the Management of Cancer Treatment-Related Gastrointestinal Mucositis and Clinical Practice Guidelines. Joanne M. Bowen, Rachel J. Gibson, Janet K. Coller, Nicole Blijlevens, Paolo Bossi, Noor Al-Dasooqi, Emma H. Bateman, karen Chiang, Charlotte de Mooij, Bronwen Mayo, Andrea M. Stringer, Wim Tissing, Hannah R. Wardill, Ysabella Z. A. Van Sebille, Vinisha Ranna, Anusha Vaddi, Dorothy M. K. Keefe, Rajesh V. Lalla, Karis Kin Fong Cheng, Sharon Elad.

Mucositis Guidelines History: 2004, 2007, 2014

The Mucositis Study Group of MASCC/ISOO published its first comprehensive review of the literature and evidence-based clinical practice guidelines in 2004, with updates in 2007 and 2014. See previous Guidelines and supporting publications.


MASCC Mucositis Guidelines ©MASCC, Multinational Association for Supportive Care in Cancer™ •  All rights reserved worldwide.
For Questions or additional information, contact Executive Director, Melissa Chin,  [email protected]