MASCC/ISOO Mucositis Clinical Practice Guidelines
©MASCC, Multinational Association for Supportive Care in Cancer™ •  All rights reserved worldwide. 


2019/20 Guidelines Update

MASCC is pleased to announce the 2019/20 update of the MASCC/ISOO Clinical Practice Guidelines for the Management of Mucositis Secondary to Cancer Therapy.

As part of this update, the MASCC Mucositis Study Group performed a systematic review and published a set of publications on various interventions for oral mucositis and gastrointestinal mucositis, pathogenesis and risk prediction.

This update proceeded the 2004, 2007, and 2014 MASCC/ISOO clinical practice guidelines for the management of mucositis.

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  Guidelines Summary (4.9 Mb powerpoint presentation)

  Current Guideline Publications

  • MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.
    Elad S et al. Cancer. 2020 Jul 28. doi: 10.1002/cncr.33100.

  • The MASCC/ISOO Mucositis Guidelines 2019 Update: introduction to the first set of article.
    Elad S. Support Care Cancer. 2019 Oct;27(10):3929-3931.

  • The MASCC/ISOO Mucositis Guidelines 2019: the second set of articles and future directions.
    Elad S. Support Care Cancer. 2020 May;28(5):2445-2447.

  • Systematic review of growth factors and cytokines for the management of oral mucositis in cancer patients and clinical practice guidelines.
    Logan RM, et al. Support Care Cancer. 2020 May;28(5):2485-2498.

  • Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and clinical practice guidelines - part 2: honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents.
    Yarom N, et al. Support Care Cancer. 2020 May;28(5):2457-2472.

  • Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients and clinical practice guidelines.
    Saunders DP, et al. Support Care Cancer. 2020 May;28(5):2473-2484.

  • Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines.
    Correa MEP, et al. Support Care Cancer. 2020 May;28(5):2449-2456.

  • Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines.
    Bowen JM, et al. Support Care Cancer. 2019 Oct;27(10):4011-4022.

  • Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines.
    Hong CHL, et al. Support Care Cancer. 2019 Oct;27(10):3949-3967.

  • Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines.
    Ariyawardana A, et al. Support Care Cancer. 2019 Oct;27(10):3985-3995.

  • Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines-part 1: vitamins, minerals, and nutritional supplements.
    Yarom N, et al. Support Care Cancer. 2019 Oct;27(10):3997-4010.

  • Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines.
    Zadik Y, et al. Support Care Cancer. 2019 Oct;27(10):3969-3983.

  • Development of the MASCC/ISOO clinical practice guidelines for mucositis: an overview of the methods.
    Ranna V, et al. Support Care Cancer. 2019 Oct;27(10):3933-3948.


Pathogenesis and Risk Prediction of Mucositis

The Mucositis Study Group conducted a systematic review focused on basic science of mucositis. This includes an update about the pathogenesis of mucositis and a new focus on risk prediction of mucositis.

  • Prediction of mucositis risk secondary to cancer therapy: a systematic review of current evidence and call to action.
    Wardill HR, et al. Support Care Cancer. 2020 Nov;28(11):5059-5073. doi: 10.1007/s00520-020-05579-7
  • The pathogenesis of mucositis: updated perspectives and emerging targets.
    Bowen J, et al.  Support Care Cancer. 2019 Oct;27(10):4023-4033. doi: 10.1007/s00520-019-04893-z

Oral Mucositis in Pediatric Patients

The Mucositis Study Group conducted a sub-analysis of their systematic review and guidelines, and concluded information pertinent to pediatric patient population.

  • MASCC/ISOO clinical practice guidelines for the management of mucositis: Sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients.
    Miranda-Silva W, Gomes-Silva W, et al. Support Care Cancer. 2020.

Mucositis Guidelines History: 2004, 2007, 2014

The Mucositis Study Group of MASCC/ISOO published its first comprehensive review of the literature and evidence-based clinical practice guidelines in 2004, with updates in 2007 and 2014. See previous Guidelines and supporting publications.


MASCC Mucositis Guidelines ©MASCC, Multinational Association for Supportive Care in Cancer™ •  All rights reserved worldwide.
For Questions or additional information, contact Executive Director, Melissa Chin,  [email protected]